Natasha Irrera Selected Research

Purinergic P1 Receptors (Adenosine Receptor)

7/2021	Targeting Adenosine Receptor by Polydeoxyribonucleotide: An Effective Therapeutic Strategy to Induce White-to-Brown Adipose Differentiation and to Curb Obesity.
2/2021	Role of Adenosine and Purinergic Receptors in Myocardial Infarction: Focus on Different Signal Transduction Pathways.
1/2018	Blockade of the Adenosine 2A Receptor Mitigates the Cardiomyopathy Induced by Loss of Plakophilin-2 Expression.
1/2018	Activation of A2A Receptor by PDRN Reduces Neuronal Damage and Stimulates WNT/β-CATENIN Driven Neurogenesis in Spinal Cord Injury.
1/2017	Adenosine Receptor Stimulation Improves Glucocorticoid-Induced Osteoporosis in a Rat Model.
1/2016	Adenosine Receptor Stimulation by Polydeoxyribonucleotide Improves Tissue Repair and Symptomology in Experimental Colitis.
1/2013	Adenosine receptor stimulation by polynucleotides (PDRN) reduces inflammation in experimental periodontitis.
10/2009	Polydeoxyribonucleotide (PDRN): a safe approach to induce therapeutic angiogenesis in peripheral artery occlusive disease and in diabetic foot ulcers.

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Natasha Irrera Research Topics

Disease

11	Wounds and Injuries (Trauma) 10/2021 - 02/2011
9	Inflammation (Inflammations) 04/2022 - 01/2013
6	Systemic Scleroderma (Systemic Sclerosis) 01/2022 - 08/2013
6	Fibrosis (Cirrhosis) 01/2022 - 08/2013
6	Necrosis 02/2021 - 12/2009
4	COVID-19 04/2022 - 01/2021
4	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2022 - 08/2013
4	Hypoxia (Hypoxemia) 10/2021 - 10/2009
4	Ischemia 10/2021 - 04/2009
4	Varicocele 01/2021 - 03/2011
4	Reperfusion Injury 01/2016 - 04/2009
4	Sepsis (Septicemia) 01/2015 - 02/2012
3	Stomatitis 02/2022 - 06/2020
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 03/2014
3	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 03/2014
3	Neuroinflammatory Diseases 01/2022 - 08/2020
3	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 11/2021 - 10/2016
3	Neoplasms (Cancer) 11/2021 - 04/2020
3	Male Infertility (Male Sterility) 01/2021 - 11/2015
3	Colitis 10/2020 - 01/2016
3	Traumatic Brain Injuries (Traumatic Brain Injury) 08/2020 - 03/2012
3	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 03/2017 - 10/2011
3	Ischemic Stroke 03/2012 - 10/2011
2	Chronic Renal Insufficiency 04/2022 - 04/2022
2	Heart Failure 04/2022 - 02/2021
2	Fuchs' Endothelial Dystrophy 04/2022 - 02/2021
2	Infections 01/2022 - 01/2020
2	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2022 - 01/2022
2	Multiple Myeloma 11/2021 - 12/2019
2	Vitiligo 10/2021 - 11/2017
2	Obesity 07/2021 - 08/2020
2	Hyperplasia 01/2021 - 10/2011
2	Weight Loss (Weight Reduction) 08/2020 - 10/2016
2	Psoriasis (Pustulosis Palmaris et Plantaris) 02/2020 - 03/2017
2	Arthritis (Polyarthritis) 01/2019 - 11/2011
2	Brain Edema (Cerebral Edema) 01/2018 - 06/2015
2	Ulcer 01/2018 - 10/2009
2	B-Cell Lymphoma (Lymphoma, B Cell) 08/2016 - 11/2015

Drug/Important Bio-Agent (IBA)

12	Proteins (Proteins, Gene)FDA Link 01/2018 - 07/2011
10	PolydeoxyribonucleotidesIBA 04/2022 - 10/2009
9	salicylhydroxamic acid (SHAM)IBA 01/2021 - 04/2009
9	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2018 - 10/2009
8	flavocoxidIBA 02/2022 - 12/2009
8	Purinergic P1 Receptors (Adenosine Receptor)IBA 07/2021 - 10/2009
8	InflammasomesIBA 01/2021 - 05/2014
7	Phosphotransferases (Kinase)IBA 01/2018 - 04/2009
6	Adenosine A2A Receptor (Adenosine A2A Receptors)IBA 04/2022 - 03/2011
6	Messenger RNA (mRNA)IBA 05/2020 - 02/2011
6	MelanocortinsIBA 03/2014 - 02/2011
5	CytokinesIBA 01/2022 - 11/2011
5	CateninsIBA 11/2021 - 01/2018
5	caryophylleneIBA 11/2021 - 01/2019
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2015 - 04/2009
4	Interleukin-6 (Interleukin 6)IBA 04/2022 - 04/2009
4	AntioxidantsIBA 02/2022 - 12/2009
4	Biological ProductsIBA 11/2021 - 01/2020
4	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2021 - 09/2013
4	SeleniumIBA 01/2021 - 03/2014
4	Testosterone (Sustanon)FDA Link 01/2021 - 10/2011
4	LycopeneIBA 05/2020 - 10/2011
4	Malondialdehyde (Propanedial)IBA 05/2020 - 11/2015
4	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 11/2015 - 04/2009
4	Melanocyte-Stimulating Hormones (MSH)IBA 03/2014 - 02/2011
3	Cannabinoid Receptors (Cannabinoid Receptor)IBA 11/2021 - 01/2019
3	CollagenIBA 10/2021 - 08/2013
3	Adenosine (Adenocard)FDA LinkGeneric 02/2021 - 11/2011
3	CadmiumIBA 01/2021 - 11/2015
3	dinitrobenzenesulfonic acidIBA 10/2020 - 01/2016
3	2,4-dinitrofluorobenzene sulfonic acidIBA 10/2020 - 01/2016
3	LipopolysaccharidesIBA 01/2019 - 01/2011
3	GenisteinIBA 09/2015 - 08/2011
3	Mitogen-Activated Protein KinasesIBA 11/2014 - 12/2009
3	Interleukin-10 (Interleukin 10)IBA 03/2012 - 02/2011
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 01/2020
2	CannabinoidsIBA 11/2021 - 06/2021
2	PolynucleotidesIBA 10/2020 - 01/2013
2	Interleukin-18 (Interleukin 18)IBA 08/2020 - 05/2014
2	Biomarkers (Surrogate Marker)IBA 08/2020 - 03/2014
2	Carotenoids (Carotene)IBA 05/2020 - 10/2011
2	Imiquimod (Aldara)FDA LinkGeneric 02/2020 - 03/2017
2	Petrolatum (Vaseline)FDA Link 02/2020 - 03/2017
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2019 - 04/2009
2	NitritesIBA 02/2018 - 02/2012
2	Cadmium Chloride (Cadmium Dichloride)IBA 01/2018 - 11/2015
2	Oxidants (Oxidizing Agents)IBA 01/2018 - 09/2013
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2017 - 03/2012
2	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 11/2017 - 09/2015
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 11/2017 - 02/2012
2	Amyloid (Amyloid Fibrils)IBA 05/2017 - 03/2014
2	SurvivinIBA 03/2017 - 01/2015
2	InterleukinsIBA 03/2017 - 04/2012
2	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 10/2016 - 06/2015
2	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 10/2016 - 06/2015
2	Ethanol (Ethyl Alcohol)IBA 10/2016 - 01/2016
2	Simvastatin (Zocor)FDA LinkGeneric 01/2016 - 08/2013

Therapy/Procedure

3	Therapeutics 04/2022 - 01/2017
3	Punctures 01/2015 - 04/2012
3	Ligation 01/2015 - 04/2012
3	Injections 09/2013 - 05/2011
2	Corneal Transplantation (Keratoplasty) 04/2022 - 02/2021